Methimazole: Uses, Interactions, Mechanism of Action - 4 minutes read

Methimazole is a medication used to treat hyperthyroidism, which is an overactive thyroid gland. It can be taken alone or in combination with other medications. Methimazole works by blocking the production of thyroid hormones and helping your body return to normal levels of those hormones. Before reading the article you can check out this AlbenPure, an online-based pharma company that recently launched “Albendazole Capsules”.You can also check out albendazole powder price from their site. However, let’s begin by diving into our main blog topic.

What is Methimazole?

Methimazole is a medication used to treat hyperthyroidism. It's also known as Tapazole, methimazole hydrochloride, and Orap.

Methimazole belongs to a class of drugs called "antithyroid drugs." These medicines block the production of thyroid hormones. Methimazole blocks the production of thyroid hormones by interfering with an enzyme called iodide-concentrating hormone (ICSH), which is involved in the synthesis of thyroid hormones.

Methimazole is used to treat hyperthyroidism, a condition caused by an overactive thyroid gland (hyperfunctioning thyroid). The medication helps to reduce the production of thyroid hormones that cause this condition.

Methimazole is also used to treat subacute thyroiditis and thyrotoxicosis caused by Graves' disease. The drug may be prescribed for other conditions as determined by your doctor.

What Is the Mechanism of Action of Methimazole?

Methimazole is a type of antithyroid medication. It works by blocking the production of thyroid hormones.

Methimazole is a thioamide, which means that it blocks the function of an enzyme called thyroid peroxidase (TPO). TPO is essential for making thyroid hormones and without it, your body makes no thyroid hormone at all.

This is the desired effect of thioamides, as it can help to reduce the production of thyroid hormones.

What Are the Off-Label Uses of Methimazole?

Methimazole is used to treat other diseases. The following are some examples of off-label uses for methimazole:

  • Graves’ disease – Methimazole can be used to treat hyperthyroidism caused by Graves’ disease, which is an autoimmune disease that causes overactive thyroid glands. Hyperthyroidism leads to symptoms such as irritability, weight loss, and heart palpitations.
  • Thyroid cancer – Methimazole may be given before surgery or radiation treatment for certain types of thyroid cancer that have not spread beyond the thyroid gland or lymph nodes.

Methimazole Interactions

There are a few medications that you should avoid while taking methimazole. Alcohol is one of them, as it can cause liver damage and may also interact with methimazole. Medications that affect the liver, heart, blood pressure, and blood sugar levels should also be avoided. Some medications like sedatives can interact with other drugs and cause too many side effects when taken together with methimazole. These include:

  • Antidepressants
  • Antipsychotics
  • Antihistamines

Methimazole Dosage and Administration

  • Take methimazole once a day, with or without food.
  • Take this medication at the same time each day, as directed by your doctor. If a dose is missed, take it as soon as possible; do not take extra medicine to make up for the missed dose if it is almost time for the next dose.
  • Do not use grapefruit juice while taking this drug because it may increase its effects on your body and cause serious side effects.

What Are the Side Effects of Methimazole?

Several side effects are possible with methimazole. This drug may cause fatigue, weakness, and muscle pain. In some cases, you might also experience:

  • Headaches
  • Nausea or vomiting
  • Diarrhea (most common in people with liver disease)

The medication methimazole is used for the treatment of hyperthyroidism.

Methimazole is a drug that blocks the production of thyroid hormones. It's often used to treat hyperthyroidism (an overactive thyroid gland) or Graves' disease, both of which can lead to heart problems, bone loss and other complications.

Methimazole works by blocking the synthesis of thyroid hormones in your body. The medication is usually used in combination with radioactive iodine (131I), which destroys the glands that produce excess levels of thyroxine and triiodothyronine (T3).


In conclusion, methimazole is a medication that's commonly used to treat hyperthyroidism. It helps by blocking the production of thyroid hormones (T3 and T4), which can be caused by Graves' disease or other conditions. This article has discussed the mechanism of action as well as off-label uses for methimazole, including its use in thyroid-low function states such as hypothyroidism or myxedema coma